IGKV2D-10

Across TCGA pan-cancer cohorts, IGKV2D-10 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGKV2D-10’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where IGKV2D-10 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2D-10 is over-expressed in tumor, although a few such as BRCA and LIHC show the opposite, repressed pattern.

BRCA, LIHC, and LUSC are the cancer types where IGKV2D-10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2D-10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.047	.005	4	view →
LIHC	Male	All	−0.028	.040	2	view →
LUSC	Female	All	−0.075	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGKV2D-10–BRCA

Open the BRCA breakdown →