IGKV2-40

Across TCGA patient cohorts, IGKV2-40 RNA expression is significantly associated with the protein abundance of many other proteins, with 5,443 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV2-40-associated proteins across cancer lineages are MZB1, ADA2, and CD38. Each is linked with IGKV2-40 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGKV2-40-to-partner and partner-to-IGKV2-40 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2-40 versus MZB1 in CCRCC, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-40→partner) and Y-score (partner→IGKV2-40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MZB1 →	+1.598	+0.239	<.001	.004	3	8
UCEC	ADA2 →	+0.410	+0.366	.005	.006	3	7
BRCA	CD38 →	+1.096	+1.019	<.001	<.001	3	7
HNSC	HCLS1 →	+0.472	+0.519	<.001	<.001	3	7
OV	LIMD2 →	+0.759	+0.897	.001	.001	3	7
LSCC	CORO1A →	+0.595	+0.877	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,443 associations by consensus.

IGKV2-40 vs MZB1 — CCRCC

Explore this scatter interactively →