IGKV2-40

Across TCGA pan-cancer cohorts, IGKV2-40 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGKV2-40 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-40 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2-40 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UCS, and STAD are the cancer types where IGKV2-40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.501	0.284	<.001	115	view →
UCS	OS	Tertile	All	0.102	0.688	<.001	108	view →
STAD	DFS	Quartile	All	0.579	0.727	.004	50	view →
SKCM	DFS	Tertile	III,IV	0.658	0.445	.002	39	view →
BRCA	DFS	Tertile	All	0.589	0.506	.012	33	view →
MESO	OS	Tertile	IV	1.000	0.470	.024	21	view →
THYM	OS	Tertile	III,IV	0.615	1.000	.019	18	view →
CESC	OS	Tertile	All	0.877	0.762	.014	18	view →
LUAD	DFS	Quartile	All	0.743	0.629	.011	14	view →
KIRC	DFS	Tertile	IV	0.961	0.575	.029	12	view →
GBM	OS	Tertile	All	0.207	0.422	.034	9	view →
THCA	DFS	Tertile	III,IV	0.961	0.648	.039	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGKV2-40–HNSC (DFS)

Open the HNSC breakdown →