IGKV2-40

Across TCGA pan-cancer cohorts, IGKV2-40 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGKV2-40’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGKV2-40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGKV2-40 is over-expressed in tumor, although a few such as READ and COAD show the opposite, repressed pattern.

LUAD, READ, and PAAD are the cancer types where IGKV2-40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2-40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.477	<.001	6	view →
READ	Female	All	−0.546	.005	2	view →
PAAD	Male	All	+0.360	.018	2	view →
HNSC	Male	III,IV	+0.271	.021	2	view →
COAD	Female	III,IV	−0.558	<.001	1	view →
LIHC	Male	All	−0.044	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGKV2-40–LUAD

Open the LUAD breakdown →