IGKV2-40

Across TCGA patient cohorts, IGKV2-40 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,165 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV2-40-associated GO terms across cancer lineages are B cell proliferation, B cell receptor signaling pathway, and B cell mediated immunity. Each is linked with IGKV2-40 in more than 22 cancer types. Because this analysis shows association rather than direction, both IGKV2-40-to-partner and partner-to-IGKV2-40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell proliferation grouped by IGKV2-40-low versus IGKV2-40-high in SKCM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-40→partner) and Y-score (partner→IGKV2-40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	B cell proliferation →	+0.064	+0.423	<.001	<.001	3	23
SARC	B cell receptor signaling pathway →	+0.101	+0.127	<.001	.001	3	23
THCA	B cell mediated immunity →	+0.113	+0.366	<.001	<.001	3	23
THCA	Immunoglobulin production →	+0.081	+0.364	<.001	<.001	3	23
SARC	T cell selection →	+0.089	+0.132	<.001	.001	3	22
SKCM	Regulation of B cell differentiation →	+0.097	+0.441	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,165 associations by consensus.

B cell proliferation by IGKV2-40 expression — SKCM

Explore this box plot interactively →