IGKV2-4

Across TCGA patient cohorts, IGKV2-4 RNA expression is significantly associated with the RNA expression of many other genes, with 5,438 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible IGKV2-4-associated genes across cancer lineages are IGHV3OR16-12, IGHV1OR15-2, and IGHV3-63. Each is linked with IGKV2-4 in more than 30 cancer types. Because this analysis shows association rather than direction, both IGKV2-4-to-partner and partner-to-IGKV2-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2-4 versus IGHV3OR16-12 in LUSC, with a Pearson correlation of 0.57.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-4→partner) and Y-score (partner→IGKV2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	IGHV3OR16-12 →	+1.103	+0.805	<.001	<.001	3	31
SARC	IGHV1OR15-2 →	+2.326	+0.260	<.001	<.001	3	30
HNSC	IGHV3-63 →	+1.677	+0.734	<.001	<.001	3	29
LUSC	IGHV3-71 →	+1.815	+0.866	<.001	<.001	3	29
HNSC	IGHV3OR15-7 →	+1.803	+0.772	<.001	<.001	3	29
LUSC	IGHV3OR16-17 →	+1.783	+0.860	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,438 associations by consensus.

IGKV2-4 vs IGHV3OR16-12 — LUSC

Explore this scatter interactively →