IGKV2-4

Across TCGA pan-cancer cohorts, IGKV2-4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV2-4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2-4 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2-4 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV2-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.200	<.001	10	view →
LUAD	All	All	+0.395	<.001	5	view →
BRCA	Female	All	−0.187	.011	4	view →
KIRC	All	All	+0.158	.001	3	view →
KIRP	Female	II,III,IV	−0.288	.042	2	view →
LIHC	Male	All	−0.148	<.001	2	view →
STAD	Male	IV	−0.779	.016	1	view →
ESCA	Female	All	−0.363	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV2-4–COAD

Open the COAD breakdown →