IGKV2-4

Across TCGA pan-cancer cohorts, IGKV2-4 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGKV2-4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and UVM are the cancer types where IGKV2-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.867	0.675	<.001	121	view →
BRCA	OS	Tertile	All	0.979	0.948	<.001	92	view →
UVM	OS	Tertile	II,III,IV	0.276	0.649	<.001	81	view →
SKCM	DFS	Tertile	All	0.698	0.575	<.001	75	view →
OV	OS	Tertile	II,III,IV	0.444	0.299	.017	66	view →
GBM	OS	Tertile	All	0.155	0.425	<.001	54	view →
UCS	OS	Tertile	II,III,IV	1.000	0.412	.010	48	view →
DLBC	OS	Tertile	All	0.599	1.000	.005	42	view →
LIHC	DFS	Tertile	III,IV	0.614	0.230	.008	42	view →
LUAD	OS	Quartile	II,III,IV	0.865	0.615	.005	18	view →
COAD	DFS	Median	All	0.829	0.740	.009	15	view →
TGCT	DFS	Median	All	0.913	0.758	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGKV2-4–HNSC (OS)

Open the HNSC breakdown →