Q-omics provides the consensus-scored IGKV2-38 profile across patient tissues and cancer cell-line models. IGKV2-38 expression is associated with patient survival in 6 of 34 cancer types, with the highest sampling consensus in STAD. Additionally, IGKV2-38 RNA expression shows 2,419 significant gene co-expression associations, with the highest sampling consensus in LUSC. Together, these results highlight STAD, and LUSC as cancer lineages where IGKV2-38 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes IGKV2-38 survival associations across molecular data types. IGKV2-38 RNA expression shows survival associations in the most cancer types (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

IGKV2-38 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	6	STAD (72)	view →

This table ranks reproducible IGKV2-38 RNA expression–survival associations across cancer types. High IGKV2-38 expression shows unfavorable associations in STAD, LUSC, COAD, UCEC, SARC and HNSC. The STAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify STAD as the clearest survival context for IGKV2-38 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.257	0.661	<.001	72	view →
LUSC	OS	Tertile	II,III,IV	0.250	0.778	.007	30	view →
COAD	DFS	Tertile	All	0.167	0.781	.002	27	view →
UCEC	DFS	Tertile	All	0.082	0.646	.009	18	view →
SARC	DFS	Tertile	All	0.159	0.614	.003	18	view →
HNSC	DFS	Tertile	All	0.168	0.663	.001	9	view →

Pink = unfavorable, green = favorable. all 6 lineages →

IGKV2-38-STAD (DFS)

Kaplan–Meier survival curve for IGKV2-38 RNA expression in STAD: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with IGKV2-38 in patient tissues and cancer cell lines. In patient samples, IGKV2-38 shows the broadest associations at the RNA and protein expression levels, with LUSC recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	2,419	LUSC (1600)	view →
Function (RNA)	1,070	HNSC (539)	view →