IGKV2-38

Across TCGA pan-cancer cohorts, IGKV2-38 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated IGKV2-38 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher IGKV2-38 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV2-38 expression acts as an unfavorable survival marker.

STAD, LUSC, and COAD are the cancer types where IGKV2-38 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	All	0.257	0.661	<.001	72	view →
LUSC	OS	Tertile	II,III,IV	0.250	0.778	.007	30	view →
COAD	DFS	Tertile	All	0.167	0.781	.002	27	view →
UCEC	DFS	Tertile	All	0.082	0.646	.009	18	view →
SARC	DFS	Tertile	All	0.159	0.614	.003	18	view →
HNSC	DFS	Tertile	All	0.168	0.663	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGKV2-38–STAD (DFS)

Open the STAD breakdown →