IGKV2-30

Across TCGA patient cohorts, IGKV2-30 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV2-30-associated genes across cancer lineages are WBP1LP6, OR2A25, and HAUS6P2. Each is linked with IGKV2-30 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-30-to-partner and partner-to-IGKV2-30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WBP1LP6 grouped by IGKV2-30-low versus IGKV2-30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-30→partner) and Y-score (partner→IGKV2-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WBP1LP6 →	+0.146	+4.923	<.001	.002	3	2
LUAD	OR2A25 →	+0.125	+4.194	<.001	.009	3	2
BLCA	HAUS6P2 →	+0.081	+5.497	<.001	.004	3	2
UCEC	NFYBP1 →	+0.671	+3.934	<.001	.002	3	2
UCEC	SFPQP1 →	+0.095	+3.156	<.001	.006	3	2
BLCA	OR52P2P →	+0.064	+6.018	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

WBP1LP6 by IGKV2-30 expression — UCEC

Explore this box plot interactively →