IGKV2-30

Across TCGA pan-cancer cohorts, IGKV2-30 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGKV2-30 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-30 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2-30 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGKV2-30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.672	0.535	<.001	144	view →
BRCA	OS	Median	All	0.976	0.948	<.001	77	view →
SKCM	OS	Tertile	All	0.843	0.715	<.001	70	view →
CESC	OS	Quartile	All	0.902	0.704	.001	34	view →
CHOL	DFS	Tertile	All	0.690	0.215	.004	27	view →
SARC	DFS	Tertile	All	0.642	0.449	<.001	24	view →
GBM	OS	Tertile	All	0.250	0.481	<.001	23	view →
KIRC	DFS	Tertile	All	0.504	0.760	.003	22	view →
LIHC	DFS	Tertile	All	0.621	0.464	.001	18	view →
COAD	OS	Tertile	IV	0.816	0.208	.001	17	view →
KIRP	DFS	Quartile	All	0.531	0.895	.008	15	view →
LUAD	DFS	Quartile	II,III,IV	0.854	0.630	.015	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGKV2-30–HNSC (DFS)

Open the HNSC breakdown →