IGKV2-29

Across TCGA patient cohorts, IGKV2-29 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,700 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV2-29-associated GO terms across cancer lineages are B cell receptor signaling pathway, B cell mediated immunity, and Antibacterial humoral response. Each is linked with IGKV2-29 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGKV2-29-to-partner and partner-to-IGKV2-29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGKV2-29-low versus IGKV2-29-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-29→partner) and Y-score (partner→IGKV2-29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.113	+2.388	<.001	<.001	3	29
CHOL	B cell mediated immunity →	+0.096	+2.283	<.001	<.001	3	28
THCA	Antibacterial humoral response →	+0.147	+1.954	<.001	<.001	3	28
THCA	Antimicrobial humoral response →	+0.097	+1.909	<.001	<.001	3	27
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.142	+1.835	<.001	<.001	3	27
CHOL	Interleukin-6 production →	+0.046	+2.801	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,700 associations by consensus.

B cell receptor signaling pathway by IGKV2-29 expression — CHOL

Explore this box plot interactively →