IGKV2-28

Across TCGA patient cohorts, IGKV2-28 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV2-28-associated genes across cancer lineages are MTCO3P9, RNA5SP365, and RAC1P1. Each is linked with IGKV2-28 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-28-to-partner and partner-to-IGKV2-28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P9 grouped by IGKV2-28-low versus IGKV2-28-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-28→partner) and Y-score (partner→IGKV2-28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTCO3P9 →	+0.074	+5.631	<.001	.004	3	1
LUAD	RNA5SP365 →	+0.501	+5.554	<.001	.004	3	1
LUAD	RAC1P1 →	+0.715	+5.410	<.001	.005	3	1
LUAD	OR10B1P →	+0.065	+5.481	<.001	.005	3	1
SKCM	OR4H12P →	+0.069	+7.810	<.001	<.001	3	1
SKCM	LINC00615 →	+0.100	+4.979	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MTCO3P9 by IGKV2-28 expression — LUAD

Explore this box plot interactively →