IGKV2-28

Across TCGA pan-cancer cohorts, IGKV2-28 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGKV2-28 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-28 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2-28 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGKV2-28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.725	0.596	<.001	144	view →
SKCM	OS	Tertile	All	0.435	0.274	<.001	103	view →
UVM	OS	Tertile	All	0.272	0.635	.001	75	view →
LUAD	DFS	Tertile	II,III,IV	0.581	0.292	.009	41	view →
COAD	OS	Tertile	IV	0.841	0.276	.009	33	view →
BRCA	OS	Median	All	0.974	0.950	.002	24	view →
TGCT	DFS	Tertile	All	0.920	0.749	.014	20	view →
GBM	DFS	Tertile	All	0.162	0.324	.039	18	view →
LGG	OS	Tertile	All	0.201	0.529	.004	15	view →
OV	DFS	Quartile	All	0.448	0.345	.019	14	view →
KIRP	OS	Quartile	All	0.471	0.777	.010	12	view →
CESC	OS	Quartile	All	0.913	0.728	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGKV2-28–HNSC (OS)

Open the HNSC breakdown →