IGKV2-28

Across TCGA pan-cancer cohorts, IGKV2-28 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGKV2-28’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2-28 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2-28 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where IGKV2-28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2-28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.054	<.001	10	view →
KIRC	Male	All	+0.621	<.001	7	view →
LUAD	Female	All	+1.347	<.001	5	view →
BRCA	Female	II,III,IV	−0.555	.002	4	view →
ESCA	All	II,III,IV	+4.330	.001	2	view →
READ	Female	All	−3.110	.001	2	view →
STAD	All	IV	−3.360	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGKV2-28–COAD

Open the COAD breakdown →