IGKV2-26

Across TCGA patient cohorts, IGKV2-26 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV2-26-associated genes across cancer lineages are OR7E129P, FOXB2, and AGBL4-AS1. Each is linked with IGKV2-26 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-26-to-partner and partner-to-IGKV2-26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E129P grouped by IGKV2-26-low versus IGKV2-26-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-26→partner) and Y-score (partner→IGKV2-26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR7E129P →	+0.043	+3.809	<.001	.003	3	1
SKCM	FOXB2 →	+0.046	+3.622	<.001	.005	3	1
SKCM	AGBL4-AS1 →	+0.138	+3.525	.004	.002	3	1
HNSC	RNU6-778P →	+0.308	+7.954	<.001	.008	3	1
LUSC	MIR1278 →	+0.566	+5.404	<.001	.005	3	1
LUSC	OR11H2 →	+0.068	+5.792	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

OR7E129P by IGKV2-26 expression — SKCM

Explore this box plot interactively →