IGKV2-26

Across TCGA pan-cancer cohorts, IGKV2-26 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV2-26 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-26 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2-26 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KIRP are the cancer types where IGKV2-26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.758	0.613	<.001	132	view →
SKCM	OS	Median	All	0.406	0.291	.001	87	view →
KIRP	DFS	Tertile	All	0.512	0.885	<.001	46	view →
GBM	OS	Tertile	All	0.216	0.428	<.001	36	view →
BRCA	OS	Median	All	0.974	0.950	.002	30	view →
LGG	OS	Tertile	All	0.506	0.808	<.001	24	view →
UVM	OS	Tertile	All	0.278	0.612	.025	18	view →
READ	OS	Tertile	III,IV	0.248	0.628	.001	17	view →
CESC	OS	Quartile	All	0.920	0.825	.031	16	view →
STAD	OS	Quartile	III,IV	0.348	0.650	.014	14	view →
PCPG	OS	Tertile	All	0.902	0.985	.022	12	view →
DLBC	OS	Quartile	II,III,IV	0.563	1.000	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV2-26–HNSC (OS)

Open the HNSC breakdown →