IGKV2-24

Across TCGA patient cohorts, IGKV2-24 protein abundance is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV2-24-associated genes across cancer lineages are RPS3, NIN, and TTI1. Each is linked with IGKV2-24 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-24-to-partner and partner-to-IGKV2-24 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2-24 versus RPS3 in BRCA, with a Pearson correlation of -0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-24→partner) and Y-score (partner→IGKV2-24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS3 →	-0.759	-1.275	.004	.004	3	1
BRCA	NIN →	+1.585	+1.125	<.001	.004	2	1
BRCA	TTI1 →	-0.535	-1.125	.002	.004	2	1
BRCA	CDADC1 →	+0.794	+1.125	.004	.004	2	1
BRCA	VIPR2 →	+0.725	+1.125	.001	.004	2	1
BRCA	MAP2K6 →	+1.390	+1.010	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

IGKV2-24 vs RPS3 — BRCA

Explore this scatter interactively →