IGKV2-24

Across TCGA pan-cancer cohorts, IGKV2-24 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV2-24 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2-24 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV2-24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.801	0.701	<.001	144	view →
SKCM	DFS	Median	All	0.728	0.530	<.001	106	view →
BRCA	OS	Median	All	0.978	0.946	<.001	103	view →
COAD	DFS	Median	All	0.760	0.625	<.001	79	view →
CESC	DFS	Quartile	All	0.824	0.641	.007	38	view →
UCEC	OS	Median	III,IV	0.676	0.473	.013	28	view →
GBM	DFS	Median	All	0.200	0.316	.005	25	view →
LIHC	DFS	Tertile	All	0.614	0.451	.002	24	view →
LUSC	OS	Quartile	II,III,IV	0.456	0.678	.003	15	view →
SARC	OS	Tertile	All	0.902	0.796	.014	10	view →
MESO	OS	Quartile	All	0.626	0.110	.006	9	view →
BLCA	DFS	Median	III,IV	0.314	0.097	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV2-24–HNSC (OS)

Open the HNSC breakdown →