IGKV2-24

Across TCGA pan-cancer cohorts, IGKV2-24 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV2-24’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2-24 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2-24 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, BRCA, and KIRC are the cancer types where IGKV2-24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2-24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.468	<.001	11	view →
BRCA	Female	II,III,IV	−1.447	<.001	6	view →
KIRC	Male	All	+1.727	<.001	5	view →
LIHC	Male	All	−2.319	<.001	4	view →
LUAD	All	All	+1.285	<.001	3	view →
ESCA	All	II,III,IV	+3.950	.024	2	view →
READ	All	All	−3.681	.001	2	view →
CHOL	All	II,III,IV	−2.409	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV2-24–COAD

Open the COAD breakdown →