IGKV2-24

Across TCGA patient cohorts, IGKV2-24 mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV2-24-associated genes across cancer lineages are SETP7, TUBAP15, and RBMY2KP. Each is linked with IGKV2-24 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-24-to-partner and partner-to-IGKV2-24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETP7 grouped by IGKV2-24-low versus IGKV2-24-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-24→partner) and Y-score (partner→IGKV2-24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SETP7 →	+0.077	+4.693	<.001	.001	3	2
LIHC	TUBAP15 →	+0.083	+4.014	<.001	.004	3	2
LUAD	RBMY2KP →	+0.054	+4.590	<.001	.004	3	2
LUAD	MIR8086 →	+0.413	+3.552	<.001	.002	3	2
SKCM	RNU6-179P →	+0.113	+3.130	.002	.006	3	2
SKCM	RNU6-414P →	+0.077	+4.351	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

SETP7 by IGKV2-24 expression — LIHC

Explore this box plot interactively →