IGKV1OR22-5

Across TCGA patient cohorts, IGKV1OR22-5 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1OR22-5-associated genes across cancer lineages are OR6K6, RNA5SP389, and RNU6-340P. Each is linked with IGKV1OR22-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1OR22-5-to-partner and partner-to-IGKV1OR22-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K6 grouped by IGKV1OR22-5-low versus IGKV1OR22-5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR22-5→partner) and Y-score (partner→IGKV1OR22-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR6K6 →	+0.115	+5.358	<.001	.006	3	1
UCEC	RNA5SP389 →	+2.570	+5.031	<.001	.009	3	1
UCEC	RNU6-340P →	+0.630	+6.027	<.001	.002	3	1
UCEC	RNA5SP72 →	+0.965	+5.031	<.001	.009	3	1
UCEC	RNA5SP131 →	+1.274	+5.551	<.001	.004	3	1
UCEC	H3C15 →	+0.056	+5.484	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR6K6 by IGKV1OR22-5 expression — UCEC

Explore this box plot interactively →