IGKV1OR22-5

Across TCGA pan-cancer cohorts, IGKV1OR22-5 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV1OR22-5 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR22-5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR22-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1OR22-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.785	0.635	<.001	144	view →
SKCM	DFS	Tertile	III,IV	0.771	0.362	<.001	83	view →
BRCA	DFS	Median	All	0.968	0.930	.001	72	view →
CHOL	DFS	Tertile	All	0.752	0.280	.005	31	view →
ESCA	OS	Quartile	II,III,IV	0.681	0.465	.030	14	view →
KIRC	DFS	Quartile	All	0.686	0.816	.011	13	view →
BLCA	DFS	Median	All	0.577	0.362	.009	12	view →
CESC	OS	Median	All	0.851	0.742	.016	12	view →
PAAD	OS	Median	II,III,IV	0.668	0.423	<.001	11	view →
READ	OS	Tertile	III,IV	0.594	0.895	.004	11	view →
TGCT	DFS	Quartile	All	0.951	0.729	.007	10	view →
MESO	OS	Median	III,IV	0.643	0.492	.039	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV1OR22-5–HNSC (DFS)

Open the HNSC breakdown →