IGKV1OR22-1

Across TCGA patient cohorts, IGKV1OR22-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,038 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1OR22-1-associated GO terms across cancer lineages are B cell receptor signaling pathway, Complement activation, classical pathway, and T cell proliferation. Each is linked with IGKV1OR22-1 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGKV1OR22-1-to-partner and partner-to-IGKV1OR22-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGKV1OR22-1-low versus IGKV1OR22-1-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR22-1→partner) and Y-score (partner→IGKV1OR22-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.094	+1.400	<.001	.001	3	28
THCA	Complement activation, classical pathway →	+0.196	+1.378	<.001	<.001	3	28
SKCM	T cell proliferation →	+0.044	+0.789	<.001	<.001	3	28
THCA	Complement activation →	+0.154	+1.349	<.001	<.001	3	27
THCA	Humoral immune response →	+0.059	+1.353	<.001	<.001	3	27
THCA	Antimicrobial humoral response →	+0.106	+1.438	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,038 associations by consensus.

B cell receptor signaling pathway by IGKV1OR22-1 expression — CHOL

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