IGKV1OR22-1

Across TCGA pan-cancer cohorts, IGKV1OR22-1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV1OR22-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR22-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR22-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where IGKV1OR22-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.791	0.630	<.001	142	view →
SKCM	DFS	Median	All	0.740	0.537	<.001	102	view →
CESC	OS	Median	All	0.868	0.720	.001	92	view →
BRCA	DFS	Quartile	All	0.643	0.467	.001	43	view →
COAD	DFS	Median	III,IV	0.754	0.446	.001	34	view →
LGG	OS	Tertile	All	0.297	0.537	<.001	27	view →
LUAD	DFS	Quartile	All	0.710	0.381	.008	26	view →
THYM	DFS	Tertile	III,IV	0.590	0.913	.022	21	view →
KICH	DFS	Quartile	II,III,IV	0.636	0.886	.035	15	view →
CHOL	DFS	Median	All	0.582	0.257	.014	14	view →
KIRP	DFS	Quartile	All	0.535	0.868	.012	14	view →
OV	DFS	Tertile	IV	0.323	0.519	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV1OR22-1–HNSC (DFS)

Open the HNSC breakdown →