IGKV1OR22-1

Across TCGA pan-cancer cohorts, IGKV1OR22-1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR22-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR22-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR22-1 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGKV1OR22-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR22-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.858	<.001	10	view →
LUAD	Female	All	+1.663	<.001	8	view →
STAD	Male	IV	−3.910	.017	7	view →
BRCA	Female	II,III,IV	−0.514	<.001	6	view →
READ	Female	All	−2.246	<.001	3	view →
KIRC	All	All	+0.338	.002	3	view →
PAAD	Female	All	−1.225	.005	2	view →
LIHC	Male	All	−0.223	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV1OR22-1–COAD

Open the COAD breakdown →