IGKV1OR2-1

Across TCGA patient cohorts, IGKV1OR2-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,246 significant associations in total. THCA shows the largest number of these associations.

The most reproducible IGKV1OR2-1-associated GO terms across cancer lineages are Immunoglobulin production, B cell mediated immunity, and Antibacterial humoral response. Each is linked with IGKV1OR2-1 in more than 21 cancer types. Because this analysis shows association rather than direction, both IGKV1OR2-1-to-partner and partner-to-IGKV1OR2-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin production grouped by IGKV1OR2-1-low versus IGKV1OR2-1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR2-1→partner) and Y-score (partner→IGKV1OR2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Immunoglobulin production →	+0.084	+0.111	<.001	<.001	3	22
THCA	B cell mediated immunity →	+0.103	+0.199	<.001	<.001	3	21
THCA	Antibacterial humoral response →	+0.160	+0.187	<.001	<.001	3	21
ESCA	B cell receptor signaling pathway →	+0.081	+0.350	<.001	<.001	2	19
ESCA	Regulation of B cell activation →	+0.044	+0.240	<.001	<.001	2	19
THCA	Complement activation, classical pathway →	+0.164	+0.183	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,246 associations by consensus.

Immunoglobulin production by IGKV1OR2-1 expression — LAML

Explore this box plot interactively →