IGKV1OR2-1

Across TCGA pan-cancer cohorts, IGKV1OR2-1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR2-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR2-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR2-1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and LUAD are the cancer types where IGKV1OR2-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR2-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.256	<.001	11	view →
READ	Male	All	−0.390	.001	6	view →
LUAD	All	All	+0.102	.013	2	view →
LUSC	Male	All	+0.170	.040	1	view →
KICH	All	All	−0.034	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGKV1OR2-1–COAD

Open the COAD breakdown →