IGKV1OR2-1

Across TCGA pan-cancer cohorts, IGKV1OR2-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGKV1OR2-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR2-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR2-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LGG are the cancer types where IGKV1OR2-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.800	0.657	.004	99	view →
LUAD	DFS	Tertile	All	0.791	0.621	<.001	54	view →
LGG	OS	Tertile	All	0.610	0.821	<.001	36	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
ESCA	DFS	Tertile	II,III,IV	0.482	0.213	.001	30	view →
STAD	DFS	Median	All	0.558	0.685	.017	21	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	18	view →
SKCM	DFS	Tertile	III,IV	0.824	0.584	.010	15	view →
GBM	OS	Tertile	All	0.282	0.424	.047	9	view →
BRCA	DFS	Tertile	All	0.590	0.507	.043	6	view →
THCA	DFS	Tertile	II,III,IV	0.747	0.889	.045	6	view →
UCS	OS	Tertile	II,III,IV	1.000	0.437	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGKV1OR2-1–HNSC (DFS)

Open the HNSC breakdown →