IGKV1OR1-1

Across TCGA patient cohorts, IGKV1OR1-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,540 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV1OR1-1-associated GO terms across cancer lineages are B cell mediated immunity, Antimicrobial humoral response, and Antibacterial humoral response. Each is linked with IGKV1OR1-1 in more than 24 cancer types. Because this analysis shows association rather than direction, both IGKV1OR1-1-to-partner and partner-to-IGKV1OR1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV1OR1-1-low versus IGKV1OR1-1-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR1-1→partner) and Y-score (partner→IGKV1OR1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.097	+0.543	<.001	<.001	3	25
SARC	Antimicrobial humoral response →	+0.110	+0.136	<.001	<.001	3	25
THCA	Antibacterial humoral response →	+0.169	+0.518	<.001	<.001	3	25
SKCM	B cell receptor signaling pathway →	+0.083	+0.318	<.001	<.001	3	24
THCA	Complement activation, classical pathway →	+0.181	+0.482	<.001	<.001	3	24
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.150	+0.468	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,540 associations by consensus.

B cell mediated immunity by IGKV1OR1-1 expression — THCA

Explore this box plot interactively →