IGKV1OR1-1

Across TCGA pan-cancer cohorts, IGKV1OR1-1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGKV1OR1-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR1-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR1-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LIHC are the cancer types where IGKV1OR1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.686	0.538	<.001	170	view →
SKCM	DFS	Quartile	All	0.722	0.588	.001	82	view →
LIHC	DFS	Tertile	All	0.714	0.524	.012	54	view →
MESO	OS	Quartile	III,IV	0.803	0.467	<.001	51	view →
GBM	OS	Tertile	All	0.215	0.426	.001	36	view →
CESC	OS	Median	All	0.868	0.753	.009	30	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	27	view →
ACC	OS	Tertile	All	0.140	0.623	.002	18	view →
ESCA	DFS	Quartile	II,III,IV	0.509	0.253	.007	16	view →
STAD	OS	Tertile	IV	0.711	0.264	.017	15	view →
KIRP	DFS	Tertile	All	0.570	0.828	.028	12	view →
BRCA	DFS	Tertile	All	0.610	0.483	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGKV1OR1-1–HNSC (DFS)

Open the HNSC breakdown →