IGKV1OR1-1

Across TCGA pan-cancer cohorts, IGKV1OR1-1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR1-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGKV1OR1-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGKV1OR1-1 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

LUAD, COAD, and STAD are the cancer types where IGKV1OR1-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR1-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.643	<.001	9	view →
COAD	Female	II,III,IV	−0.822	<.001	8	view →
STAD	All	All	−0.604	.021	4	view →
BRCA	Female	All	−0.157	.005	4	view →
READ	All	All	−0.856	.001	3	view →
PAAD	Female	All	−0.360	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGKV1OR1-1–LUAD

Open the LUAD breakdown →