IGKV1D-8

Across TCGA patient cohorts, IGKV1D-8 protein abundance is significantly associated with the RNA expression of many other genes, with 3,562 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV1D-8-associated genes across cancer lineages are TLR4, CALHM5, and CSRNP1. Each is linked with IGKV1D-8 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGKV1D-8-to-partner and partner-to-IGKV1D-8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1D-8 versus TLR4 in CCRCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-8→partner) and Y-score (partner→IGKV1D-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TLR4 →	+0.958	+0.877	.004	.005	3	3
CCRCC	CALHM5 →	+0.732	+0.901	.003	.006	3	3
GBM	CSRNP1 →	+0.826	+1.109	<.001	.005	3	3
BRCA	AREG →	+1.968	+0.415	<.001	.005	3	2
BRCA	MMP13 →	+1.501	+0.407	.004	.008	3	2
BRCA	FCGR2A →	+0.662	+0.534	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,562 associations by consensus.

IGKV1D-8 vs TLR4 — CCRCC

Explore this scatter interactively →