IGKV1D-8

Across TCGA pan-cancer cohorts, IGKV1D-8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV1D-8 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where IGKV1D-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.783	0.635	<.001	140	view →
UCEC	OS	Quartile	III,IV	0.819	0.339	<.001	112	view →
SKCM	DFS	Quartile	III,IV	0.490	0.183	<.001	103	view →
BRCA	DFS	Tertile	All	0.970	0.921	<.001	84	view →
LGG	DFS	Median	All	0.476	0.336	<.001	48	view →
LUAD	DFS	Tertile	All	0.871	0.764	.002	38	view →
KIRP	DFS	Quartile	All	0.522	0.879	.004	29	view →
GBM	DFS	Quartile	All	0.145	0.360	<.001	24	view →
COAD	DFS	Tertile	All	0.656	0.497	.010	20	view →
CESC	OS	Median	All	0.861	0.729	.002	20	view →
TGCT	DFS	Median	All	0.924	0.740	.005	16	view →
KIRC	OS	Median	All	0.773	0.835	.017	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV1D-8–HNSC (DFS)

Open the HNSC breakdown →