IGKV1D-8

Across TCGA patient cohorts, IGKV1D-8 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV1D-8-associated genes across cancer lineages are RNU4-58P, RNY4P6, and MIR16-1. Each is linked with IGKV1D-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-8-to-partner and partner-to-IGKV1D-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by IGKV1D-8-low versus IGKV1D-8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-8→partner) and Y-score (partner→IGKV1D-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU4-58P →	+0.213	+3.963	<.001	.003	3	2
HNSC	RNY4P6 →	+0.411	+3.473	<.001	.005	3	2
HNSC	MIR16-1 →	+0.249	+5.623	<.001	.001	3	2
HNSC	VPS26BP1 →	+0.101	+4.561	<.001	<.001	3	2
HNSC	MIR6752 →	+0.281	+4.339	<.001	.007	3	2
SKCM	TRAJ43 →	+0.338	+2.788	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

RNU4-58P by IGKV1D-8 expression — HNSC

Explore this box plot interactively →