IGKV1D-43

Across TCGA patient cohorts, IGKV1D-43 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,971 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1D-43-associated GO terms across cancer lineages are Complement activation, B cell mediated immunity, and Antimicrobial humoral response. Each is linked with IGKV1D-43 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGKV1D-43-to-partner and partner-to-IGKV1D-43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation grouped by IGKV1D-43-low versus IGKV1D-43-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-43→partner) and Y-score (partner→IGKV1D-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Complement activation →	+0.146	+1.161	<.001	<.001	3	30
CHOL	B cell mediated immunity →	+0.107	+1.445	<.001	<.001	3	29
THCA	Antimicrobial humoral response →	+0.103	+1.271	<.001	<.001	3	29
THCA	Antibacterial humoral response →	+0.158	+1.291	<.001	<.001	3	29
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.153	+1.183	<.001	<.001	3	29
CHOL	B cell receptor signaling pathway →	+0.090	+0.870	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,971 associations by consensus.

Complement activation by IGKV1D-43 expression — THCA

Explore this box plot interactively →