IGKV1D-43

Across TCGA patient cohorts, IGKV1D-43 protein abundance is significantly associated with the RNA expression of many other genes, with 562 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV1D-43-associated genes across cancer lineages are PPIL2, DYRK1B, and CYTH2. Each is linked with IGKV1D-43 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-43-to-partner and partner-to-IGKV1D-43 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1D-43 versus PPIL2 in LUAD, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-43→partner) and Y-score (partner→IGKV1D-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPIL2 →	+0.389	+0.588	.006	.002	3	1
LUAD	DYRK1B →	+0.470	+0.406	.002	.004	3	1
LUAD	CYTH2 →	+0.713	+0.496	.001	.004	3	1
LUAD	RAB3D →	+0.907	+0.593	<.001	.001	3	1
LUAD	SIPA1L3 →	+0.698	+0.398	.004	.005	3	1
LUAD	IQCE →	+0.716	+0.460	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 562 associations by consensus.

IGKV1D-43 vs PPIL2 — LUAD

Explore this scatter interactively →