IGKV1D-43

Across TCGA patient cohorts, IGKV1D-43 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1D-43-associated genes across cancer lineages are MEP, Basophils, and Plasma cells. Each is linked with IGKV1D-43 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-43-to-partner and partner-to-IGKV1D-43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP grouped by IGKV1D-43-low versus IGKV1D-43-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-43→partner) and Y-score (partner→IGKV1D-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MEP →	+0.028	+2.830	.009	.034	3	1
LUSC	Basophils →	+0.146	+2.321	.020	.036	3	1
LUSC	Plasma cells →	+0.016	+2.357	.039	.019	3	1
UCEC	Neurons →	-0.021	-3.148	.043	.020	2	1
UCEC	CMP →	-0.043	-3.159	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEP by IGKV1D-43 expression — LUSC

Explore this box plot interactively →