IGKV1D-33

Across TCGA patient cohorts, IGKV1D-33 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV1D-33-associated genes across cancer lineages are RNU6-1040P, MIR515-2, and DPP10-AS2. Each is linked with IGKV1D-33 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-33-to-partner and partner-to-IGKV1D-33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1040P grouped by IGKV1D-33-low versus IGKV1D-33-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-33→partner) and Y-score (partner→IGKV1D-33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1040P →	+0.497	+7.930	<.001	.008	3	1
LUAD	MIR515-2 →	+0.958	+7.930	<.001	.008	3	1
LUAD	DPP10-AS2 →	+0.114	+7.930	<.001	.008	3	1
LUAD	RPS29P26 →	+0.348	+7.930	<.001	.008	3	1
LUAD	RNU6-982P →	+1.021	+7.930	<.001	.008	3	1
LUAD	RNU6-751P →	+0.518	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

RNU6-1040P by IGKV1D-33 expression — LUAD

Explore this box plot interactively →