IGKV1D-33

Across TCGA pan-cancer cohorts, IGKV1D-33 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGKV1D-33 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-33 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-33 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGKV1D-33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.673	0.533	<.001	144	view →
SKCM	DFS	Median	All	0.687	0.566	<.001	76	view →
UVM	OS	Tertile	All	0.334	0.726	.010	45	view →
THYM	DFS	Median	All	0.779	0.982	.012	42	view →
KIRP	DFS	Quartile	All	0.529	0.841	.003	36	view →
BRCA	DFS	Median	All	0.968	0.929	.001	35	view →
MESO	OS	Median	All	0.698	0.320	.015	34	view →
CHOL	DFS	Tertile	All	0.742	0.281	.006	33	view →
LGG	OS	Tertile	All	0.477	0.805	.001	27	view →
COAD	DFS	Median	IV	0.670	0.286	.006	23	view →
GBM	OS	Tertile	All	0.217	0.475	<.001	18	view →
BLCA	DFS	Quartile	III,IV	0.690	0.535	.022	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGKV1D-33–HNSC (DFS)

Open the HNSC breakdown →