IGKV1D-17

Across TCGA patient cohorts, IGKV1D-17 mutation is significantly associated with the RNA expression of many other genes, with 386 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1D-17-associated genes across cancer lineages are BNIP3P6, FBXO7, and RNU1-96P. Each is linked with IGKV1D-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-17-to-partner and partner-to-IGKV1D-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P6 grouped by IGKV1D-17-low versus IGKV1D-17-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-17→partner) and Y-score (partner→IGKV1D-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BNIP3P6 →	+0.059	+7.954	<.001	.008	3	2
UCEC	FBXO7 →	+0.470	+3.212	.007	.009	3	2
HNSC	RNU1-96P →	+0.169	+7.954	<.001	.008	3	2
BLCA	BORCS7-ASMT →	+0.018	+4.588	<.001	.008	3	1
BLCA	C14orf177 →	+0.052	+6.082	<.001	<.001	3	1
BLCA	RN7SKP118 →	+0.143	+4.685	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 386 associations by consensus.

BNIP3P6 by IGKV1D-17 expression — HNSC

Explore this box plot interactively →