IGKV1D-17

Across TCGA pan-cancer cohorts, IGKV1D-17 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGKV1D-17 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-17 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-17 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGKV1D-17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.750	0.641	<.001	141	view →
BRCA	DFS	Quartile	All	0.570	0.417	.001	39	view →
SKCM	OS	Median	All	0.843	0.704	.006	23	view →
BLCA	OS	Median	All	0.500	0.247	.009	19	view →
OV	DFS	Median	III,IV	0.185	0.122	.010	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
MESO	OS	Median	All	0.625	0.455	.015	13	view →
CHOL	DFS	Median	All	0.608	0.238	.016	12	view →
LGG	DFS	Tertile	All	0.621	0.838	.011	12	view →
COAD	OS	Median	III,IV	0.791	0.581	.013	11	view →
LUAD	DFS	Median	II,III,IV	0.658	0.472	.021	11	view →
READ	DFS	Tertile	IV	0.889	0.377	.008	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGKV1D-17–HNSC (DFS)

Open the HNSC breakdown →