IGKV1D-16

Across TCGA patient cohorts, IGKV1D-16 mutation is significantly associated with the RNA expression of many other genes, with 235 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1D-16-associated genes across cancer lineages are RNU6-1019P, RNU6-628P, and RN7SL726P. Each is linked with IGKV1D-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-16-to-partner and partner-to-IGKV1D-16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1019P grouped by IGKV1D-16-low versus IGKV1D-16-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-16→partner) and Y-score (partner→IGKV1D-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1019P →	+0.599	+3.624	.004	.008	3	2
LUSC	RNU6-628P →	+0.356	+3.333	.003	.004	3	2
BRCA	RN7SL726P →	+0.335	+5.317	<.001	.006	3	2
BLCA	RNU6-1114P →	+0.632	+3.719	<.001	.008	3	2
BRCA	MIR199B →	+0.545	+5.175	<.001	.007	3	2
HNSC	RNU6-552P →	+0.202	+4.636	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 235 associations by consensus.

RNU6-1019P by IGKV1D-16 expression — LUSC

Explore this box plot interactively →