IGKV1D-16

Across TCGA pan-cancer cohorts, IGKV1D-16 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV1D-16 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-16 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGKV1D-16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.753	0.638	<.001	135	view →
BRCA	DFS	Tertile	All	0.970	0.921	<.001	85	view →
SKCM	OS	Tertile	All	0.417	0.264	.001	62	view →
UCS	OS	Median	II,III,IV	0.748	0.454	.010	46	view →
CESC	OS	Quartile	All	0.916	0.705	.001	30	view →
GBM	OS	Quartile	All	0.168	0.468	<.001	21	view →
LGG	OS	Tertile	All	0.691	0.902	<.001	18	view →
CHOL	DFS	Tertile	All	0.830	0.134	.013	15	view →
LUAD	DFS	Median	III,IV	0.628	0.330	.021	15	view →
KIRP	DFS	Quartile	All	0.509	0.861	.004	13	view →
BLCA	DFS	Tertile	All	0.448	0.119	.008	12	view →
COAD	DFS	Quartile	IV	0.876	0.143	<.001	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV1D-16–HNSC (DFS)

Open the HNSC breakdown →