IGKV1D-13

Across TCGA patient cohorts, IGKV1D-13 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1D-13-associated genes across cancer lineages are RNA5SP408, YWHAZP1, and EEF1E1-BLOC1S5. Each is linked with IGKV1D-13 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-13-to-partner and partner-to-IGKV1D-13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP408 grouped by IGKV1D-13-low versus IGKV1D-13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-13→partner) and Y-score (partner→IGKV1D-13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP408 →	+0.920	+5.186	<.001	.007	3	2
UCEC	YWHAZP1 →	+0.135	+5.242	.004	.007	3	2
LUSC	EEF1E1-BLOC1S5 →	+0.074	+3.748	<.001	.008	3	2
HNSC	RNU6-744P →	+0.266	+4.822	<.001	.006	3	1
HNSC	TXNP7 →	+0.145	+4.508	.008	.005	3	1
HNSC	GYPB →	+0.028	+4.780	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RNA5SP408 by IGKV1D-13 expression — UCEC

Explore this box plot interactively →