IGKV1D-13

Across TCGA pan-cancer cohorts, IGKV1D-13 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGKV1D-13’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1D-13 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1D-13 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGKV1D-13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1D-13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.456	.001	8	view →
LUAD	All	All	+1.220	<.001	3	view →
KIRC	Male	All	+0.831	.001	3	view →
BRCA	Female	II,III,IV	−0.567	.023	3	view →
READ	All	All	−1.677	.014	2	view →
HNSC	All	III,IV	+1.244	.026	1	view →
LIHC	Male	All	−0.864	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGKV1D-13–COAD

Open the COAD breakdown →