IGKV1D-13

Across TCGA pan-cancer cohorts, IGKV1D-13 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGKV1D-13 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-13 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and UCEC are the cancer types where IGKV1D-13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.522	0.226	<.001	114	view →
BRCA	OS	Tertile	All	0.603	0.506	<.001	92	view →
UCEC	DFS	Median	III,IV	0.861	0.715	.005	92	view →
SKCM	OS	Quartile	All	0.840	0.708	<.001	83	view →
UCS	OS	Median	II,III,IV	0.743	0.477	.025	26	view →
MESO	OS	Quartile	II,III,IV	0.704	0.495	.008	17	view →
LUAD	DFS	Median	All	0.830	0.697	.003	17	view →
SARC	OS	Median	All	0.824	0.661	.015	12	view →
READ	OS	Tertile	III,IV	0.241	0.628	.001	12	view →
CHOL	DFS	Median	All	0.757	0.128	.012	9	view →
CESC	OS	Quartile	II,III,IV	0.911	0.722	.036	8	view →
DLBC	DFS	Median	III,IV	0.383	0.984	.043	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGKV1D-13–HNSC (DFS)

Open the HNSC breakdown →