IGKV1D-12

Across TCGA patient cohorts, IGKV1D-12 protein abundance is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1D-12-associated genes across cancer lineages are PLEKHA4, GLB1L2, and ACAN. Each is linked with IGKV1D-12 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-12-to-partner and partner-to-IGKV1D-12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1D-12 versus PLEKHA4 in BRCA, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-12→partner) and Y-score (partner→IGKV1D-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLEKHA4 →	+2.670	+1.236	<.001	.005	3	1
BRCA	GLB1L2 →	+2.246	+1.256	.008	.004	3	1
BRCA	ACAN →	+0.573	+1.025	.001	.003	3	1
BRCA	PSMG3-AS1 →	+1.186	+1.236	.005	.005	3	1
BRCA	TUSC2 →	+0.901	+1.380	.008	.009	2	1
BRCA	ETV3 →	+0.931	+1.380	.005	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

IGKV1D-12 vs PLEKHA4 — BRCA

Explore this scatter interactively →