IGKV1D-12

Across TCGA pan-cancer cohorts, IGKV1D-12 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGKV1D-12’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1D-12 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1D-12 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGKV1D-12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1D-12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.397	<.001	9	view →
LUAD	Female	All	+1.388	<.001	5	view →
KIRC	Male	All	+0.462	.005	3	view →
READ	All	All	−1.637	.001	2	view →
PAAD	Male	All	+1.150	.047	2	view →
CHOL	All	II,III,IV	−0.240	.006	2	view →
STAD	All	IV	−3.260	.040	1	view →
LIHC	Female	III,IV	−0.296	.011	1	view →
KICH	All	All	−0.290	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGKV1D-12–COAD

Open the COAD breakdown →